![]() ![]() We investigated whether this differential change in inhibitory/excitatory inputs leads to altered neuronal excitability. While soma-localized ACh/GABA co-transmission showed depression of the GABA component with repeated stimulation, ACh-mediated nicotinic responses were largely maintained. In response to repeated stimulation the GABA conductance found on lateral dendrites decremented less than the proximally located GABA conductance, and was more effective at inhibiting action potentials. There was a predominant GABA-only conductance along lateral dendrites and soma-centered ACh/GABA co-transmission. We identified three types of monosynaptic cholinergic inputs spatially arranged onto medial substantia nigra dopaminergic neurons in male and female mice: co-transmitted acetylcholine (ACh)/GABA, GABA only, and ACh only. ![]()
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